ACTH (4-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
An endogenous peptide fragment of ACTH
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包装价格促销价数量
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1mg￥612.00490.00- +
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5mg￥2012.001610.00- +
- 货号: ajcx17512
- CAS: N/A
- 别名: Adrenocorticotropic Hormone (4-10), Corticotropin (4-10)
- 分子式: C44H59N13O10S ? XCF3COOH
- 分子量: 962.1
- 纯度: ＞98%
- 溶解度: Water: 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Adrenocorticotropic hormone (ACTH) (4-10) is an endogenous peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response. ACTH (4-10) is found in the septal nuclei, the third ventricle, and ventral horn motor neurons. The amino acid sequence of ACTH (4-10) is common to ACTH and the α- and β-melanocyte stimulating hormones. ACTH (4-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 23 and 330 nM for the human recombinant receptors, respectively). It increases mean arterial pressure (ED50 = 287 nmol/kg) and heart rate (ED50 = 313 nmol/kg) in rats. It also improves aortic and coronary blood flow and left ventricular developed pressure following cardiac ischemia and reperfusion when administered at a dose of 200 µg/kg in rats, as well as reduces the infarct size and decreases caspase-3 activity. ACTH (4-10) (10 µg per animal) accelerates motor function improvements in a rat model of sciatic nerve crush.
