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- Cyclooxygenase (COX)
- (±)8(9)-EET
(±)8(9)-EET
A racemic version of a CYP450 metabolite of arachidonic acid
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包装价格促销价数量
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25ug￥600.00480.00- +
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50ug￥1087.00870.00- +
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100ug￥1800.001440.00- +
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500ug￥7737.006190.00- +
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- 货号: ajcx17588
- CAS: N/A
- 别名: (±)8,9EpETrE
- 分子式: C20H32O3
- 分子量: 320.5
- 纯度: ＞98%
- 溶解度: DMF: ＞50 mg/ml (per Rao Maddipati),DMSO: ＞50 mg/ml (per Rao Maddipati),Ethanol: ＞50 mg/ml (per Rao Maddipati),PBS pH 7.2: ＞1 mg/ml (from 13(S)-HODE)
- 储存: Store at -20°C
- 库存: 现货
Background
(±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid . (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARα in HEK293 cells when used at a concentration of 1 µM but inhibits NF-κB activity induced by IL-1β in a PPARα-dependent and -independent fashion. It is also a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM. (8S,9R)-EET (1 µg/kg), but not (8R,9S)-EET, reduces the glomerular filtration rate (GFR) through COX-dependent pre-glomerular vasoconstriction in rats.
