MAGL Inhibitor Compound 23

An inhibitor of MAGL

原价

￥612-6712

价格

￥ 490-5370

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库存: 现货

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产品引用

货号: ajcx17672
CAS: 2324160-91-8
别名:
分子式: C22H24FNO3
分子量: 369.4
纯度: >98%
溶解度: DMF: 25 mg/ml,DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml,DMSO: 20 mg/ml,Ethanol: 2.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

MAGL inhibitor compound 23 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 80 nM). It is selective for MAGL over cannabinoid receptor 1 (CB1), CB2, fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing protein 6 (ABHD6), and ABHD12 (IC50s = >10 μM). MAGL inhibitor compound 23 inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells (IC50s = 21, 7.9, 25, 57, and 15 μM, respectively) but not MRC5 cells (IC50 = >100 μM). It increases the levels of 2-arachidonoyl glycerol in mouse brain and plasma when administered at a dose of 50 mg/kg.

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MAGL Inhibitor Compound 23

MAGL Inhibitor Compound 23详情

Background