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- Cyclooxygenase (COX)
- (±)19(20)-EpDPA
(±)19(20)-EpDPA
A DHA epoxygenase metabolite
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包装价格促销价数量
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25ug￥675.00540.00- +
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50ug￥1287.001030.00- +
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100ug￥2450.001960.00- +
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500ug￥10837.008670.00- +
- 货号: ajcx17674
- CAS: N/A
- 别名: (±)19,20 EDP, (±)19,20-epoxy Docosapentaenoic Acid, (±)19,20-epoxy DPA, (±)19,20-EpDPE
- 分子式: C22H32O3
- 分子量: 344.5
- 纯度: ＞98%
- 溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)19(20)-EpDPA is a DHA epoxygenase metabolite, derived via epoxidation of the ω-3 double bond of DHA. The EDHF activity of (±)19(20)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.
