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- DNA Methyltransferase
- K-TMZ
K-TMZ
A DNA alkylating agent
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥1750.001400.00- +
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5mg￥4362.003490.00- +
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10mg￥6975.005580.00- +
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- 货号: ajcx17692
- CAS: 2269482-26-8
- 别名:
- 分子式: C7H7N5O2
- 分子量: 193.2
- 纯度: ＞98%
- 溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.
