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An epoxygenase metabolite of DHA
Docosahexaenoic acid is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. (±)19(20)-DiHDPA is one of the major metabolites produced when DHA is incubated with NADPH-supplemented rat liver microsomes. DHA is also slowly metabolized by monkey seminal vesicles to (±)19(20)-DiHDPA. The route of production likely proceeds through cytochrome P450-catalyzed epoxidation at the ω-3 double bond, followed by conversion to the vicinal diols by epoxide hydrolase.
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