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- PKC (Protein kinase C)
- (Des-octanoyl)-Ghrelin (human) (trifluoroacetate salt)
(Des-octanoyl)-Ghrelin (human) (trifluoroacetate salt)
A peptide hormone
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包装价格促销价数量
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500ug￥2662.002130.00- +
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1mg￥4762.003810.00- +
- 货号: ajcx17728
- CAS: N/A
- 别名:
- 分子式: C141H235N47O41?XCF3COOH
- 分子量: 3244.7
- 纯度: ＞98%
- 溶解度: Water: 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R). Ghrelin requires an n-octanoyl modification at serine 3 for binding to the growth hormone (GH) secretagogue receptor (GHS-R). (Des-octanoyl)-ghrelin (human) is a form of ghrelin that is lacking the octanoyl group at serine 3. It is located in the mouse stomach and is expressed at a lower level than octanoyl ghrelin. (Des-octanoyl)-ghrelin activates GHS-R by only 41% when used at 10 µM (IC50 = >10,000 nM; EC50 = >10,000 nM for increasing calcium accumulation). It induces bone marrow adipogenesis in rat models of growth hormone deficiency. (Des-octanoyl)-ghrelin also inhibits cell proliferation in estrogen-dependent MCF-7 breast cancer cells (EC50 = 0.81 µM) but induces proliferation of a somatotroph pituitary tumor cell line, an effect that can be blocked by MAPK, PKC, and tyrosine kinase inhibitors.
