(R)-(-)-Linoleyl-2'-Hydroxy-1'-Propylamide

LOEA的同源物

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库存: 现货

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1mg

￥1362.00

1090.00

- +
5mg

￥6025.00

4820.00

- +
10mg

￥10700.00

8560.00

- +

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货号: ajcx17736
CAS: N/A
别名:
分子式: C21H39NO2
分子量: 337.5
纯度: >98%
溶解度: DMF: 11 mg/ml,DMSO: 5 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 11 mg/ml
储存: Store at -20°C
库存: 现货

Background

N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning.^1,2 LOEA has a weak affinity for cannabinoid (CB) receptors (K_i = 10, 25 μM for CB₁, CB₂, respectively) and inhibits voltage-gated K⁺ channels.^3,4 LOEA also inhibits fatty acid amide drolase (FAAH; K_i = 9 μM) and is drolyzed by FAAH.^5,6 (R)-(?)-Linoleyl-2’-droxy-1’-propylamide is a homolog of LOEA which is characterized by the addition of an (R)-β-metl group at the terminal ethanolamine carbon. A similar modification of arachidonoyl ethanolamide to produce R-2 methanandamide imparts diminished affinity for the CB receptor as well as reduced metabolic stability.⁷ The psiological actions of this compound have not been evaluated.