(S)-(-)-Linoleyl-1'-Hydroxy-2'-Propylamide

LOEA的同源物

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库存: 现货

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数量
1mg

￥1362.00

1090.00

- +
5mg

￥6025.00

4820.00

- +
10mg

￥10700.00

8560.00

- +

已选 0 种 0 瓶

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货号: ajcx17744
CAS: N/A
别名:
分子式: C21H39NO2
分子量: 337.5
纯度: ＞98%
溶解度: DMF: 11 mg/ml,DMSO: 5 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
储存: Store at -20°C
库存: 现货

Background

N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning.^1,2 LOEA has a weak affinity for cannabinoid (CB) receptors (K_i = 10 and 25 μM for CB₁ and CB₂, respectively).³ It also inhibits fatty acid amide drolase (FAAH; K_i = 9 μM) and is drolyzed by FAAH, and inhibits voltage-gated K⁺ channels.^4,5,6 (S)-(?)-Linoleyl-1’-droxy-2’-propylamide is a homolog of LOEA, characterized by the addition of an (S)-α-metl group at the metlene carbon adjacent to the amide nitrogen. A similar modification of arachidonoyl ethanolamide to produce S-1 methanandamide results in a diminished affinity for the CB receptor but greatly improved metabolic stability to aminopeptidase drolysis.⁷ The psiological actions of this compound have not been evaluated.

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信号通路

生命科学

有机化学

无机化学

材料科学

(S)-(-)-Linoleyl-1'-Hydroxy-2'-Propylamide

(S)-(-)-Linoleyl-1'-Hydroxy-2'-Propylamide详情

Background

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