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- 2'3'-cGAMP (sodium salt)
2'3'-cGAMP (sodium salt)
A second messenger and inducer of IFN-β production
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包装价格促销价数量
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500ug￥4637.003710.00- +
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1mg￥8800.007040.00- +
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- 货号: ajcx17844
- CAS: N/A
- 别名: Guanosine-Adenosine 2',3'-cyclic monophosphate, 2'-3'-Cyclic GMP-AMP
- 分子式: C20H22N10O13P2?2Na
- 分子量: 718.4
- 纯度: ＞98%
- 溶解度: Water: Soluble
- 储存: Store at -20°C
- 库存: 现货
Background
2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA. It contains a non-canonical 2'5'-phosphodiester bond and binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value of 3.79 nM, which is significantly lower than that observed for 2'2'-cGAMP, 3'3'-cGAMP , cyclic di-GMP , and 3'2'-cGAMP (Kds = 0.287, 1.04, 1.21, and 1.61 µM, respectively). It is a potent inducer of IFN-β mRNA expression with an EC50 value of 19.4 nM in L929 cells.
