2'3'-cGAMP (sodium salt)

A second messenger and inducer of IFN-β production

原价

￥4637-8800

价格

￥ 3710-7040

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库存: 现货

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产品引用

货号: ajcx17844
CAS: N/A
别名: Guanosine-Adenosine 2',3'-cyclic monophosphate, 2'-3'-Cyclic GMP-AMP
分子式: C20H22N10O13P2?2Na
分子量: 718.4
纯度: >98%
溶解度: Water: Soluble
储存: Store at -20°C
库存: 现货

Background

2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA. It contains a non-canonical 2'5'-phosphodiester bond and binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value of 3.79 nM, which is significantly lower than that observed for 2'2'-cGAMP, 3'3'-cGAMP , cyclic di-GMP , and 3'2'-cGAMP (Kds = 0.287, 1.04, 1.21, and 1.61 µM, respectively). It is a potent inducer of IFN-β mRNA expression with an EC50 value of 19.4 nM in L929 cells.

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信号通路

生命科学

有机化学

无机化学

材料科学

2'3'-cGAMP (sodium salt)

2'3'-cGAMP (sodium salt)详情

Background