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A potent agonist of PAR2
2-furoyl-LIGRLO amide is a potent and selective agonist of the proteinase-activated receptor, PAR2 (pD2 = 7.0). It does not activate PAR1 or PAR4. Through its effects on PAR2, 2-furoyl-LIGRLO amide produces a concentration-dependent relaxation of arteries previously contracted with α1 adrenergic receptor agonists.
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