An internal standard for the quantification of 3-bromotyrosine
3-Bromotyrosine-13C9,15N is intended for use as an internal standard for the quantification of 3-bromotyrosine by GC- or LC-MS. 3-Bromotyrosine is a product of protein oxidation found after activation of eosinophils during an allergic response. It has been used as a marker of eosinophil peroxidase-induced protein oxidation in vitro and in vivo. In addition to its production in eosinophils, 3-bromotyrosine is found at 5-fold higher levels in peritoneal exudate from mice infected with K. pneumoniae compared with uninfected animals, suggesting neutrophils release higher levels of oxidized products during inflammation. In a human study, 3-bromotyrosine was increased in allergen-challenged lung samples from subjects with allergen-induced asthma.
动态评分
0.0