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- 8-bromo-Cyclic ADP-Ribose (sodium salt)
8-bromo-Cyclic ADP-Ribose (sodium salt)
An inhibitor of cADP-ribose signaling
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1mg￥7787.006230.00- +
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- 货号: ajcx18012
- CAS: N/A
- 别名: 8-bromo-cADPR, 8-bromo-cADP-Ribose
- 分子式: C15H18BrN5O13P2 ? 2Na
- 分子量: 664.2
- 纯度: ＞98%
- 溶解度: Water: Soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD+ by cADP-ribose synthases, including CD38. cADP-Ribose appears to activate calcium channels in intracellular membranes, which in turn activate ryanodine receptors. 8-bromo-cADP-Ribose is a stable, cell-permeable analog that blocks calcium release evoked by cADP-ribose in sea urchin egg homogenates with an IC50 value of 1.7 µM. It is commonly used to investigate intracellular signaling through cADP-ribose in isolated cells and tissues.
