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- Acetyl-CoA carboxylase (ACC)
- Amylin (human) (trifluoroacetate salt)
Amylin (human) (trifluoroacetate salt)
An antidiabetic peptide that forms amyloid fibrils
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包装价格促销价数量
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500ug￥4612.003690.00- +
- 货号: ajcx18084
- CAS: N/A
- 别名: IAPP (human), Islet Amyloid Polypeptide (human)
- 分子式: C165H260N50O56S2?XCF3COOH
- 分子量: 3904.3
- 纯度: ＞98%
- 溶解度: Formic Acid: 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values of 2 and 0.2 nM for porcine and guinea pig nucleus accumbens membrane preparations, respectively. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes. Amylin forms fibrils that react to thioflavin T and are organized in a cross-β arrangement of β-strands similar to amyloid-β (1-40) and amyloid-β (1-42) fibrils., Aggregated amylin (60 μM) decreases the viability of primary pancreatic islet cell cultures by 60%. It also inhibits electrically-stimulated contractions of guinea pig vas deferens (EC50 = 213 nM).
