Amylin (rat, mouse) (trifluoroacetate salt)

A peptide hormone

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库存: 现货

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500ug

￥4900.00

3920.00

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货号: ajcx18086
CAS: N/A
别名: IAPP (rat, mouse), Islet Amyloid Polypeptide (rat, mouse)
分子式: C167H272N52O53S2?XCF3COOH
分子量: 3920.4
纯度: >98%
溶解度: Water: 1 mg/ml
储存: Store at -20°C ,protect from light
库存: 现货

Background

Amylin is a 37-residue peptide hormone secreted by pancreatic β-cells that reduces food intake, modifies glycogen synthesis, slows gastric emptying, and increases satiety. It binds to heteromeric complexes of human calcitonin receptor 2 (CTR2) with receptor activity-modifying protein (RAMP) 1 or 3 (IC50s = 7.86 and 6.35 nM, respectively). It also binds to mouse α-thyroid-stimulating hormone thyrotroph (α-TSH) cells (IC50 = 10.5 nM) and rat nucleus accumbens membrane preparations (Ki = 0.024 nM). In vitro, amylin (100 nM) inhibits insulin-induced, but not basal, glycogen synthesis in hepatocytes isolated from fasted rats. It also inhibits insulin-induced glycogen synthesis ex vivo in isolated soleus muscle from fasted rats. In vivo, amylin delays gastric emptying in rats (ED50 = 69 pmol) and decreases food intake in fasted mice (ED50 = 110 μg/kg). Unlike human amylin , rat amylin does not form fibrils and is not cytotoxic.