Amyloid-β (17-40) Peptide (human) (trifluoroacetate salt)
A 24-residue amyloid-β protein fragment
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包装价格促销价数量
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500ug￥4062.003250.00- +
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1mg￥7725.006180.00- +
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- 货号: ajcx18090
- CAS: N/A
- 别名: Aβ (17-40)
- 分子式: C110H178N26O31S?XCF3COOH
- 分子量: 2392.8
- 纯度: ＞98%
- 溶解度: Formic Acid: 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Amyloid-β (Aβ) (17-40) is a 24-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases. In vitro, Aβ (17-40) polymerizes into lattice-like structures that do not bind thioflavin T. It inhibits interactions between fibrinogen and biotinylated Aβ (1-42) as well as between cholesterol and apolipoprotein E (ApoE) with IC50 values of 13.4 and 25 μM, respectively. Aβ (17-40) increases the rate of Aβ (1-40) aggregation in vitro when used at an equimolar concentration. Aβ (17-40) (25 μM) induces cell death in cultured rat hippocampal neurons.
