A synthetic peptide precursor of angiotensin I
Angiotensinogen (1-14), also known as tetradecapeptide (TDP), is a synthetic peptide precursor of angiotensin I that corresponds to amino acids 1-14 of endogenous human angiotensinogen. Angiotensinogen (1-14) is cleaved by renin at the Leu-Val peptide bond to release angiotensin I, which is then converted to angiotensin II by angiotensin converting enzyme (ACE) and exerts vasoconstrictive properties. Angiotensinogen (1-14) (0.001-1 μM) induces contraction of isolated rat femoral resistance vessels, an effect that is reduced by the angiotensin II receptor partial antagonist saralasin and enhanced by the serine protease kallikrein.
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