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安捷凯生物医药，安捷凯化学
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  2. Reactive oxygen species (ROS)
  3. APC 366 (trifluoroacetate salt)
  • APC 366 (trifluoroacetate salt)
APC 366 (trifluoroacetate salt)的可视化放大

APC 366 (trifluoroacetate salt)

A mast cell tryptase inhibitor

原价
￥1012-4525
价格
￥ 810-3620
APC 366 (trifluoroacetate salt)的二维码

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  • 库存: 现货
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  • 货号: ajcx18106
  • CAS: N/A
  • 别名:
  • 分子式: C22H28N6O4?XCF3COOH
  • 分子量: 440.5
  • 纯度: >98%
  • 溶解度: Ethanol:Water: 5 mg/ml (in 20% EtOH)
  • 储存: Store at -20°C
  • 库存: 现货

Background

APC 366 is a mast cell tryptase inhibitor (Ki = 7.1 μM for human recombinant enzyme). It reduces maximum contractile response to histamine in isolated bronchial tissue from ovalbumin-sensitized guinea pigs when used at a concentration of 1 μM. Aerosolized APC 366 (5 mg in 1 ml of water) reduces airway resistance and increases dynamic lung compliance in A. suum antigen-challenged pigs. It also reduces collagen content and expression of protease-activated receptor 2 (PAR-2) and α-smooth muscle actin (α-SMA) in rat liver in a model of bile duct ligation-induced liver fibrosis.

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