CALP1 (trifluoroacetate salt)

A calcium-like peptide

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥3087.00

2470.00

- +
5mg

￥13637.00

10910.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajcx18230
CAS: N/A
别名: Calcium-like Peptide 1
分子式: C40H75N9O10?XCF3COOH
分子量: 842.1
纯度: >98%
溶解度: DMF: 5 mg/ml,DMSO: 5 mg/ml,Ethanol: 0.5 mg/ml,PBS (pH 7.2): 0.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site. It binds to calmodulin (Kd = 88 µM) and activates phosphodiesterase in the presence of calmodulin and absence of calcium. CALP1 also acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons thereby inhibiting excitatory cytotoxicity (IC50 = 52.48 µM) and apoptosis (IC50 = 44.78 µM). CALP1 (1 mg/kg) pretreatment prevents increases in lung alveolar inflammatory cells after six, but not 24, hours in sensitized guinea pigs challenged with ovalbumin in a model of allergic asthma. It also decreases radical production induced by phorbol 12-myristate 13-acetate in broncho-alveolar lavage cells after six and 24 hours and dose-dependently decreases histamine-induced hyperresponsiveness in isolated guinea pig tracheal rings.