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  2. Apoptosis
  3. Carfilzomib Impurity 13 (hydrochloride)
  • Carfilzomib Impurity 13 (hydrochloride)
Carfilzomib Impurity 13 (hydrochloride)的可视化放大

Carfilzomib Impurity 13 (hydrochloride)

A potential impurity found in commercial carfilzomib preparations

原价
￥2875-5412
价格
￥ 2300-4330
Carfilzomib Impurity 13 (hydrochloride)的二维码

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  • 库存: 现货
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  • 货号: ajcx18236
  • CAS: N/A
  • 别名:
  • 分子式: C16H22N2O4?HCl
  • 分子量: 342.8
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Carfilzomib impurity 13 (hydrochloride) is a potential impurity found in commercial carfilzomib preparations. Carfilzomib is a second-generation, irreversible, peptide epoxyketone class proteasome inhibitor that targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases. It can induce cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, lymphoma, and various solid tumors (IC50s = 2.4-20 nM).

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