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  3. Clozapine N-oxide (hydrochloride)
  • Clozapine N-oxide (hydrochloride)
Clozapine N-oxide (hydrochloride)的可视化放大

Clozapine N-oxide (hydrochloride)

A metabolite of clozapine and muscarinic DREADD agonist

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￥ 0-980
Clozapine N-oxide (hydrochloride)的二维码

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  • 库存: 现货
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  • 货号: ajcx18274
  • CAS: 2250025-93-3
  • 别名: CNO
  • 分子式: C18H19ClN4O?2HCl
  • 分子量: 415.7
  • 纯度: >98%
  • 溶解度: DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Clozapine N-oxide is a major metabolite of clozapine and an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (EC50s = 16.7, 323, 17.4, 18.3, and 18.7 nM for PASMCs expressing hM1-5D receptors, respectively). It prevents action potential firing in cultured hippocampal neurons transiently expressing hM4D receptors. Clozapine N-oxide increases glutamate in the nucleus accumbens core and inhibits cue-induced reinstatement of cocaine-seeking behavior in rats transfected with hM3Dq DREADD receptors.

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