C-Type Natriuretic Peptide-22 (human, porcine, rat) (trifluoroacetate salt)

A peptide with diverse biological activities

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
500ug

￥3287.00

2630.00

- +
1mg

￥5537.00

4430.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

C-Type natriuretic peptide-22 (CNP-22) is an endogenous peptide with diverse biological activities. Its 22 amino acid sequence corresponds to residues 105-126 of its precursors prepro CNP, pro CNP, and CNP-53. CNP-22 is a selective agonist of natriuretic peptide receptors (NPRs) 2 and 3 (Kds = 7, 10.8, and >500,000 pM for NPR2, 3, and 1, respectively). It stimulates cGMP accumulation in HEK293 cells expressing rat NPR2 (ED50 = 2.2 nM) and relaxes isolated rat cerebral arterioles (EC50 = 0.52 nM). In vivo, CNP-22 (25 μg/kg) decreases kidney injury and oxidative and inflammatory responses in a rat model of hemorrhagic shock.