Cyclic di-IMP (sodium salt)
A synthetic second messenger
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包装价格促销价数量
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500ug￥2875.002300.00- +
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1mg￥5412.004330.00- +
- 货号: ajcx18298
- CAS: N/A
- 别名: c-di-IMP, Cyclic di-inosine monophosphate
- 分子式: C20H20N8O14P2?2Na
- 分子量: 704.3
- 纯度: ＞98%
- 溶解度: Water: 50 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) plus c-di-IMP through the intranasal route show a humoral immune response, evidenced by an increase in IgG titers up to 2-fold compared to mice immunized with β-gal alone. Mice immunized with β-gal plus c-di-IMP also exhibit a Th1/Th2 response, indicating that the adjuvant activity of c-di-IMP leads to a cellular immune response as well.
