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- D-myo-Inositol-1,3,4-triphosphate (sodium salt)
D-myo-Inositol-1,3,4-triphosphate (sodium salt)
An inositol phosphate
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包装价格促销价数量
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100ug￥712.00570.00- +
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500ug￥3262.002610.00- +
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1mg￥5737.004590.00- +
- 货号: ajcx18360
- CAS: N/A
- 别名: Ins(1,3,4)P3 (sodium salt), 1,3,4IP3 (sodium salt)
- 分子式: C6H12O15P3?3Na
- 分子量: 486
- 纯度: ＞98%
- 溶解度: PBS pH 7.2: ＞50 mg/ml (from D-myo-Inositol
- 储存: Store at -20°C
- 库存: 现货
Background
The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals. D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels. The levels of Ins(1,3,4)-P3 are in turn regulated by the levels of cytosolic free calcium. The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs, leading to a dramatic but transient increase in the cytosolic concentration of free calcium.
