A synthetic, pure phosphoinositol for signal transduction research
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D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling. Ins(1)P1 can be formed by PLC hydrolysis of phosphatidylinositol or by dephosphorylation of polyphosphate inositols such as Ins(1,3)P2 by inositol polyphosphate 3-phosphatase. Changes in myo-inositol-1-phosphate synthase activity and inositol levels are induced by lithium and valproate and are associated with bipolar disorder. Also, cross-regulation occurs between the SUMO and inositol pathways.