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- D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt)
D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt)
An inhibitor of Ca2+ activated chloride channels
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包装价格促销价数量
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100ug￥2275.001820.00- +
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500ug￥10162.008130.00- +
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1mg￥17887.0014310.00- +
- 货号: ajcx18384
- CAS: N/A
- 别名: Ins(3,4,5,6)P4, 3,4,5,6IP4
- 分子式: C6H12O18P4?4Na
- 分子量: 588
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt) (Ins(3,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. It almost completely inhibits calcium-activated chloride channels at a concentration of 8-10 µM. Related inositol oligophosphates Ins(1,3,4,5)-P4, Ins(1,3,4,6)-P4, Ins(1,4,5,6)-P4, and Ins(1,3,4,5,6)-P5 do not inhibit the calcium channel at concentrations up to 100 µM. Ins(1,3,4)P3-mediated inhibition of Ins(3,4,5,6)-P4 1-kinase increases the cellular level of Ins(3,4,5,6)-P4, thus regulating channel inhibition. Ins(3,4,5,6)-P4 was found to be inactive when analyzed for Ca2+-releasing potency in Xenopus oocytes.
