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  • Dutasteride-13C6
Dutasteride-13C6的可视化放大

Dutasteride-13C6

An internal standard for the quantification of dutasteride

原价
¥7987-15025
价格
6390-12020
Dutasteride-13C6的二维码

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  • 库存: 现货
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  • 货号: ajcx18420
  • CAS: N/A
  • 别名:
  • 分子式: C21[13C]6H30F6N2O2
  • 分子量: 534.5
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Dutasteride-13C6 is intended for use as an internal standard for the quantification of dutasteride by GC- or LC-MS. Dutasteride is a dual inhibitor of 5α-reductase types I and II (Kis = 6 and 7 nM, respectively). Its inhibition is time-dependent with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively. Dutasteride decreases prostate weight in a rat model of benign prostatic hypertrophy induced by testosterone after castration when administered daily for 28 days at doses of 0.045 mg/kg as a solution or 0.756 mg/kg in subcutaneous microspheres. It also decreases prostate weight in large probasin-large T antigen mice, a transgenic model of prostate cancer. Formulations containing dutasteride have been used in the treatment of benign prostatic hyperplasia.

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