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- Endothelin Receptor
- Endothelin-3 (human, rat) (trifluoroacetate salt)
Endothelin-3 (human, rat) (trifluoroacetate salt)
A peptide vasoconstrictor
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包装价格促销价数量
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100ug￥3292.002634.00- +
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250ug￥5703.004563.00- +
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500ug￥7335.005868.00- +
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1mg￥8148.006519.00- +
- 货号: ajcx18436
- CAS: N/A
- 别名: ET-3
- 分子式: C121H168N26O33S4?XCF3COOH
- 分子量: 2643
- 纯度: ＞98%
- 溶解度: Water: 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively). It induces β-arrestin recruitment in CHO-K1 cells expressing human ETA and ETB (pD2s = 7.31 and 9.44, respectively). Endothelin-3 increases blood pressure in spontaneously hypertensive and normotensive rats when administered at doses of 310 and 955 pmol/kg, respectively. It also stimulates migration and adhesion of enteric neural crest cells (ENCCs) to the embryonic gut in mice via interaction with ETB. Mutations in the endothelin-3 gene, Edn3, induce distal aganglionosis caused by failed colonization of ENCCs in the hindgut and lack of ENCC migration to the ileo-caecal junction in mice.
