Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively).
货号:ajcx18436
CAS:N/A
分子式:C121H168N26O33S4 ? XCF3COOH
分子量：2643
溶解度:Water: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货
Background:
Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively).1 It induces β-arrestin recruitment in CHO-K1 cells expressing human ETA and ETB (pD2s = 7.31 and 9.44, respectively). Endothelin-3 increases blood pressure in spontaneously hypertensive and normotensive rats when administered at doses of 310 and 955 pmol/kg, respectively.2 It also stimulates migration and adhesion of enteric neural crest cells (ENCCs) to the embryonic gut in mice via interaction with ETB.3 Mutations in the endothelin-3 gene, Edn3, induce distal aganglionosis caused by failed colonization of ENCCs in the hindgut and lack of ENCC migration to the ileo-caecal junction in mice.
参考文献：
1. Maguire, J.J., Kuc, R.E., Pell, V.R., et al. Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways. Life Sci. 91(13-14), 544-549 (2012).
2. Watanabe, T.X., Kumagaye, S., Nishio, H., et al. Effects of endothelin-1 and endothelin-3 on blood pressure in conscious hypertensive rats. J. Cardiovasc. Pharmacol. 13(Suppl 5), S207-S208 (1989).
3. Gazquez, E., Watanabe, Y., Broders-Bondon, F., et al. Endothelin-3 stimulates cell adhesion and cooperates with β1-integrins during enteric nervous system ontogenesis. Sci. Rep. 6(37877), 1-14 (2016).
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