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Substrate for JmjC domain-containing class of histone demethylases
Histone H3 undergoes many modifications including acetylation, methylation, and phosphorylation that are important for regulation of gene transcription. This histone H3 peptide contains a trimethylated lysine residue at position nine which is a substrate for several of the JmjC domain-containing class of histone demethylases. JMJD2A and JMJD2D exhibit higher affinity with H3K9me3 compared to H3K9me2.
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