Histone H3K27Me2 (21-44)-GK-biotin (trifluoroacetate salt)

A biotinylated peptide fragment of histone H3

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货号: ajcx18568
CAS: N/A
别名: ATKAAR-K(Me2)-SAPATGGVKKPHRYRPG-GK(Biotin), Histone H3 (21-24) (Lys27me2)-GK(Biotin), Lys(Me2)27-Histone H3 (21-44)-GK(Biotin) (trifluoroacetate salt)
分子式: C129H218N44O33S?XCF3COOH
分子量: 2945.5
纯度: >98%
溶解度: Water: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Histone H3K27Me2 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences. It is dimethylated at lysine 27 and biotinylated via a C-terminal GK linker. Dimethylation of H3K27 is present on large chromatin domains across approximately 70% of total histone H3 and prevents firing of non-cell type-specific enhancers. H3K27Me2 accumulates in gene bodies of genes with low levels of expression in mouse embryonic stem cells. Histone H3K27Me2 (21-44)-GK-biotin has been used as a positive control in a high-throughput screen for inhibitors of the histone demethylase jumonji AT-rich interactive domain 1B (JARID1B).