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- Histone Methyltransferase
- Histone H3K4Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
Histone H3K4Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
A peptide fragment of histone H3
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包装价格促销价数量
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250ug￥3087.002470.00- +
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1mg￥11012.008810.00- +
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- 货号: ajcx18590
- CAS: N/A
- 别名: ART-K(Me3)-QTARKSTGGKAPRKQLA, H3K4(Me3), Histone H3 (1-21) (Lys4me3), Lys(Me3)4-Histone H3 (1-21)
- 分子式: C97H178N36O28?XCF3COOH
- 分子量: 2296.7
- 纯度: ＞98%
- 溶解度: Water: 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Histone H3K4Me3 (1-21) is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-22 of the human histone H3 sequence. Trimethylation of histone H3 at lysine 4 is found in euchromatic promoter regions and is associated with active transcription. It inhibits several H3K9 methyltransferases and has differential effects on the activities of the KDM7 demethylases PHF8 and KDM7A, activating and inhibiting H3K9Me3 demethylation, respectively. Mislocalization of H3K4Me3 is associated with disease progression and memory deficits in patients with Alzheimer's disease.
