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  2. Reactive oxygen species (ROS)
  3. LX7101 (hydrochloride)
  • LX7101 (hydrochloride)
LX7101 (hydrochloride)的可视化放大

LX7101 (hydrochloride)

A LIMK and ROCK inhibitor

原价
￥937-6462
价格
￥ 750-5170
LX7101 (hydrochloride)的二维码

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  • 库存: 现货
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  • 货号: ajcx18642
  • CAS: 2319882-48-7
  • 别名:
  • 分子式: C23H29N7O3?HCl
  • 分子量: 488
  • 纯度: >98%
  • 溶解度: DMF: 3 mg/ml,DMSO: 3 mg/ml,PBS (pH 7.2): 5 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, showing no cross reactivity in a panel of binding assays including 78 receptors and transporters and 430 additional kinases, at a concentration of 10 μM. Topical administration (3 μl of 1 mg/ml solution) of LX7101 to the eye reduces intraocular pressure in a dexamethasone-induced mouse model of glaucoma.

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