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- Reactive oxygen species (ROS)
- LX7101 (hydrochloride)
LX7101 (hydrochloride)
A LIMK and ROCK inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥937.00750.00- +
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5mg￥3687.002950.00- +
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10mg￥6462.005170.00- +
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- 货号: ajcx18642
- CAS: 2319882-48-7
- 别名:
- 分子式: C23H29N7O3?HCl
- 分子量: 488
- 纯度: ＞98%
- 溶解度: DMF: 3 mg/ml,DMSO: 3 mg/ml,PBS (pH 7.2): 5 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, showing no cross reactivity in a panel of binding assays including 78 receptors and transporters and 430 additional kinases, at a concentration of 10 μM. Topical administration (3 μl of 1 mg/ml solution) of LX7101 to the eye reduces intraocular pressure in a dexamethasone-induced mouse model of glaucoma.
