Lyso-Monosialoganglioside GM1 (ammonium salt)

A sphingolipid

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库存: 现货

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500ug

￥8937.00

7150.00

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货号: ajcx18646
CAS: N/A
别名: Lysoganglioside GM1, Lyso-GM1, lyso-Monosialoganglioside GM1
分子式: C55H96N3O30?NH4
分子量: 1297.4
纯度: >98%
溶解度: Chloroform:Methanol:Water (2:1:0.1): Soluble
储存: Store at -20°C
库存: 现货

Background

Lyso-monosialoganglioside GM1 (Lyso-GM1) is a form of ganglioside GM1 that is lacking the fatty acyl group. Lyso-GM1 (2.5 µM) inhibits laminin-1-induced clustering of ganglioside GM1 in dorsal root ganglion (DRG) cells and also disrupts β1 integrin clustering and neurite outgrowth. It does not protect against glutamate-induced neurotoxicity in primary neuronal cultures. Elevated levels of lyso-GM1 have been found in the brain and spinal cord of patients with infantile- and late-infantile-type GM1-gangliosidosis, a neurodegenerative disorder characterized by deficiency of the enzyme β-galactosidase and accumulation of gangliosides.