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- ML-252 (hydrochloride)
ML-252 (hydrochloride)
A potent and selective inhibitor of Kv7.2 channels
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包装价格促销价数量
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1mg￥675.00540.00- +
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5mg￥1875.001500.00- +
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10mg￥3412.002730.00- +
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- 货号: ajcx18680
- CAS: N/A
- 别名:
- 分子式: C20H24N2O?HCl
- 分子量: 344.9
- 纯度: ＞98%
- 溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 2 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
ML-252 is a potent and selective inhibitor of the voltage-gated potassium channel subtype Kv7.2 (IC50 = 69 nM in a patch clamp assay). It is the (S)-enantiomer and is more potent than the (R)-enantiomer and the racemic mixture (IC50s = 944 and 160 nM, respectively). It is selective for Kv7.2 over other Kv channel subtypes, >68 G protein-coupled receptors, transporters, L- and N-type calcium channels, and KATP and hERG potassium channels though it does inhibit the melatonin MT1 receptor 61% when used at a concentration of 10 µM.
