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- Ribosomal S6 Kinase (RSK)
- Peptide YY (human) (trifluoroacetate salt)
Peptide YY (human) (trifluoroacetate salt)
A peptide agonist for Y1, Y2, Y5, and Y6 receptors
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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500ug￥3087.002470.00- +
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1mg￥5500.004400.00- +
- 货号: ajcx18840
- CAS: N/A
- 别名: Peptide Tyrosine Tyrosine
- 分子式: C194H295N55O57?XCF3COOH
- 分子量: 4309.8
- 纯度: ＞98%
- 溶解度: Water: 1 mg/ml
- 储存: Store at -20°C,protect from light
- 库存: 现货
Background
Peptide YY (PYY) is a 36-amino acid peptide and anorectic gut hormone agonist for the neuropeptide Y receptors Y1, Y2, Y5, and Y6 with EC50 values of 0.7, 0.58, 1, and 0.8 nM, respectively, for supression of forskolin-induced cAMP accumulation. PYY is cleaved in vivo to PYY (3-36) . Release of PYY occurs postprandially in proportion to calorie intake from intestinal enteroendocrine L cells, indicating it may be a satiety signal. In humans, PYY inhibits food intake and gastrointestinal transit in both lean and obese subjects.
Reference:
[1]. Gerald, C., Walker, M.W., Criscione, L., et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382(6587), 168-171 (1996).
[2]. Mullins, D.E., Guzzi, M., Xia, L., et al. Pharmacological characterization of the cloned neuropeptide Y y6 receptor. Eur. J. Pharmacol. 395(2), 87-93 (2000).
[3]. Holzer, P., Reichmann, F., and Farzi, A. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis. Neuropeptides 46(6), 261-274 (2012).
