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- Reactive oxygen species (ROS)
- Prostaglandin F2α diethyl amide
Prostaglandin F2α diethyl amide
A PGF2α analog
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包装价格促销价数量
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1mg￥875.00700.00- +
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5mg￥3875.003100.00- +
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10mg￥6900.005520.00- +
- 货号: ajcx18890
- CAS: N/A
- 别名: Dinoprost diethyl amide, PGF2α diethyl amide, PGF2αNEt2
- 分子式: C24H43NO4
- 分子量: 409.6
- 纯度: ＞98%
- 溶解度: DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 100 μ g/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Prostaglandin F2α diethyl amide (PGF2α-NEt2) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various PGs to the free acids with a conversion efficiency of about 4 µg/g corneal tissue/hr. However, we find that dialkyl amides such as PGF2α-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids. These compounds may therefore be useful tools in elucidating the claim that PG amides have intrinsic intraocular hypotensive activity.
