PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl) (sodium salt)
An inositol phospholipid with possible roles in signal transduction
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包装价格促销价数量
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50ug￥1487.001190.00- +
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100ug￥2825.002260.00- +
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500ug￥11825.009460.00- +
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1mg￥19912.0015930.00- +
- 货号: ajcx18916
- CAS: N/A
- 别名: PI(3,4,5)P3, PI(P-18:0/20:4), PIP33,4,5(18:0/20:4), Phosphatidylinositol3,4,5triphosphate C18 (sodium salt)
- 分子式: C47H82O22P4?4Na
- 分子量: 1215
- 纯度: ＞98%
- 溶解度: CHCl3:CH3OH:Water (3:2:1): 10 mg/ml,PBS (pH 7.2): Freely soluble
- 储存: Store at -20°C
- 库存: 现货
Background
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and Akts are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC. Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references and .
