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- ALK (Anaplastic lymphoma kinase)
- SN-38 Glucuronide (trifluoroacetate salt)
SN-38 Glucuronide (trifluoroacetate salt)
A phase II metabolite of irinotecan
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包装价格促销价数量
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1mg￥9550.007640.00- +
- 货号: ajcx18982
- CAS: N/A
- 别名: SN-38G
- 分子式: C28H28N2O11?XCF3COOH
- 分子量: 568.5
- 纯度: ＞98%
- 溶解度: Slightly soluble in DMSO, Slightly soluble in Methanol
- 储存: Store at -20°C
- 库存: 现货
Background
SN-38 glucuronide is an inactive metabolite of irinotecan , which is a derivative of the alkaloid camptothecin. [1] SN-38 glucuronide is formed by glucuronidation of SN-38 , the active metabolite of irinotecan, by UDP glucuronosyl transferase 1A1 (UGT1A1) and UGT1A7. It can also be formed in COS-7 cells by UGT1A1 and UGT1A10, which are both up-regulated in an irinotecan/SN-38-resistant cell line. [2]?
Reference:
[1]. Mathijssen, R.H.J., van Alphen, R.J., Verweij, J., et al. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). Clin. Cancer Res. 7(8), 2182-2194 (2001).
[2]. Oguri, T., Takahashi, T., Miyazaki, M., et al. UGT1A10 is responsible for SN-38 glucuronidation and its expression in human lung cancers. Anticancer Res. 24(5A), 2893-2896 (2004).
