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- Histone Methyltransferase
- UNC0321 (trifluoroacetate salt)
UNC0321 (trifluoroacetate salt)
A highly potent inhibitor of G9a histone methyltransferase
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包装价格促销价数量
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1mg￥787.00630.00- +
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5mg￥1962.001570.00- +
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10mg￥3550.002840.00- +
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50mg￥13525.0010820.00- +
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- 货号: ajcx19044
- CAS: 1934302-25-6
- 别名:
- 分子式: C27H45N7O3?3(CF3COOH)
- 分子量: 857.8
- 纯度: ＞98%
- 溶解度: DMF: 10 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 5 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0321 is a potent and selective G9a HMTase inhibitor, exhibiting a Ki value of 63 pM. UNC0321 inhibits G9a with assay-dependent IC50 values of 6-9 nM and GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 15-23 nM. It is more than 40,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and JMJD2E.
