UNC2170 (maleate)

A 53BP1 antagonist

原价

￥712-11687

价格

￥ 570-9350

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库存: 现货

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产品引用

货号: ajcx19046
CAS: N/A
别名:
分子式: C14H21BrN2O?C4H4O4
分子量: 429.3
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

p53-Binding protein 1 (53BP1) binds to dimethylated lysine 20 on histone 4 (H4K20me2) via tandem tudor domains on a 53BP1 homodimer. This interaction is an important part of the DNA damage response. UNC2170 is a micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains. It displays at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. UNC2170 functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain.

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生命科学

有机化学

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材料科学

UNC2170 (maleate)

UNC2170 (maleate)详情

Background