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  • Vapreotide (trifluoroacetate salt)
Vapreotide (trifluoroacetate salt)的可视化放大

Vapreotide (trifluoroacetate salt)

A peptide NK1 receptor antagonist

原价
¥2037-2662
价格
1630-2130
Vapreotide (trifluoroacetate salt)的二维码

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  • 货号: ajcx19054
  • CAS: N/A
  • 别名: BMY 41606, Octastatin, RC 160
  • 分子式: C57H70N12O9S2?XCF3COOH
  • 分子量: 1131.4
  • 纯度: >98%
  • 溶解度: Water: 1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Vapreotide is a peptide neurokinin-1 receptor (NK1) antagonist and analog of somatostatin (IC50 = 330 nM in a radioligand binding assay). It inhibits increases in vascular permeability stimulated by substance P in a concentration-dependent manner in isolated guinea pig trachea and main bronchi. Vapreotide (8 nmol per animal) reduces substance P-induced biting and scratching in mice. It increases reaction time to heat stimuli in the hot plate and tail flick tests when administered at a dose of 512 μg/kg, indicating antinociceptive activity in mice. Vapreotide reduces plasma growth hormone (GH) increases induced by phenobarbital , morphine , and chlorpromazine , hypoglycemia-induced glucagon elevation, and glucose-induced insulin secretion in rats. It also decreases tumor weight and volume in a hamster model of pancreatic ductal adenocarcinoma and suppresses tumor growth and reduces GH secretion in SK-ES-1 and MNNG/HOS osteosarcoma mouse xenograft models.

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