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  • α-CGRP (8-37) (human) (trifluoroacetate salt)
α-CGRP (8-37) (human) (trifluoroacetate salt)的可视化放大

α-CGRP (8-37) (human) (trifluoroacetate salt)

An antagonist of CGRP receptors

原价
¥2662-4762
价格
2130-3810
α-CGRP (8-37) (human) (trifluoroacetate salt)的二维码

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  • 货号: ajcx19080
  • CAS: N/A
  • 别名: Calcitonin Gene-Related Peptide-1 (8-37) (human), CGRP-1 (8-37) (human), α-Calcitonin Gene-Related Peptide (8-37) (human)
  • 分子式: C139H230N44O38?XCF3COOH
  • 分子量: 3125.6
  • 纯度: >98%
  • 溶解度: Water: 1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Calcitonin gene-related protein (CGRP) is a neuropeptide and a product of alternative splicing of the calcitonin gene. It induces vasodilation of both arteries and veins in addition to various non-vascular biological activities. α-CGRP (8-37) is an antagonist of CGRP receptors (IC50 = 4.9 nM in SK-N-MC cells expressing the human receptor) that inhibits CGRP-induced vasodilation. In a mouse model of headache, α-CGRP (8-37) application to the dura mater reduces behavior induced by application of capsaicin and inflammatory mediators. α-CGRP (8-37) (human) is a peptide fragment derived from the human CGRP protein sequence.

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