α-CGRP (rat) (trifluoroacetate salt)

A neuropeptide with diverse biological activities

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库存: 现货

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500ug

￥5937.00

4750.00

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1mg

￥11275.00

9020.00

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货号: ajcx19084
CAS: N/A
别名: Calcitonin Gene-Related Peptide-1 (rat), α-Calcitonin Gene-Related Peptide (rat), CGRP-1 (rat)
分子式: C162H262N50O52S2?XCF3COOH
分子量: 3806.3
纯度: >98%
溶解度: Water: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

α-Calcitonin gene-related peptide (α-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin , and adrenomedullin. α-CGRP binds selectively to heterotrimeric complexes of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins RAMP 1 or 3 (RAMP1 and 3; IC50s = 7 and 23 nM, respectively) over a complex of CLCR and RAMP2 (IC50 = >1,000 nM). It binds to rat brain and spleen membrane preparations (IC50s = 3.9 and 3.5 nM, respectively) and relaxes human cerebral and middle meningeal arterial segments precontracted with prostaglandin F2α . In vivo, α-CGRP (0.01-3,000 ng/kg) decreases mean arterial blood pressure (MABP) and increases pial arteriole (PA) and middle meningeal artery (MMA) diameters in rats with closed cranial windows. It induces a 50% increase in diameter of arterioles precontracted with human endothelin-1 in vivo in hamster cheek pouch at a concentration of 39.8 pM.