β-CGRP (human) (trifluoroacetate salt)

A neuropeptide with diverse biological activities

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库存: 现货

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500ug

￥3212.00

2570.00

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1mg

￥6050.00

4840.00

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货号: ajcx19100
CAS: N/A
别名: α-Calcitonin Gene-Related Peptide (human), Calcitonin Gene Related Peptide-1 (human), CGRP-1 (human)
分子式: C162H267N51O48S3?XCF3COOH
分子量: 3793.4
纯度: >98%
溶解度: Water: 1 mg/ml
储存: Store at -20°C, protect from light
库存: 现货

Background

β-Calcitonin gene-related peptide (β-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation. It belongs to the calcitonin family of peptides, which also includes α-CGRP , amylin , calcitonin , and adrenomedullin. β-CGRP binds selectively to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1; IC50 = 0.01 nM) over a complex of CLCR and RAMP2 (IC50 = 300 nM). It binds to rat brain and spleen membrane preparations (IC50s = 1.1 and 1 nM, respectively) and relaxes human cerebral and middle meningeal arterial segments precontracted with prostaglandin F2α . In vivo, β-CGRP induces a 50% increase in diameter of arterioles precontracted with human endothelin-1 in hamster cheek pouch at a concentration of 15.8 pM.