7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one
A turn-on fluorescent probe for hydrogen sulfide
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包装价格促销价数量
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1mg￥512.00410.00- +
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5mg￥2337.001870.00- +
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10mg￥4100.003280.00- +
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25mg￥9000.007200.00- +
- 货号: ajcx19272
- CAS: 314742-00-2
- 别名:
- 分子式: C16H10N2O7
- 分子量: 342.3
- 纯度: ＞98%
- 溶解度: Chloroform: 30mg/mL,DMF: 30mg/mL,DMF:PBS (pH 7.2) (1:2): 0.30mg/mL,DMSO: 5mg/mL
- 储存: Store at -20°C
- 库存: 现货
Background
7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one is a turn-on fluorescent probe for the detection of hydrogen sulfide (H2S).1 7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one undergoes thiolysis by hydrogen sulfide (HS1-). It displays excitation/emission maxima of 323/445 nm, respectively, in DMSO and its fluorescence intensity increases in the presence of sulfur-containing molecules.2,3,1 7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one is selective for sulfur-containing molecules, including cysteine, glutathione (GSH), homocysteine, and selenocysteine and is not cytotoxic up to a concentration of 150 μg/ml.1,2
参考文献
1. Chen, Y., Shang, X., Li, C., et al. The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives. Sci. Rep. 8(1), 16159 (2018).
2. Zhang, B., Ge, C., Yao, J., et al. Selective selenol fluorescent probes: Design, synthesis, structural determinants, and biological applications. J. Am. Chem. Soc. 137(2), 757-769 (2015).
3. Yang, X.F., Su, Z., Liu, C., et al. A thiol-selective fluorogenic probe based on the cleavage of 4-methylumbelliferyl-2',4',6'-trinitropheyl ether. Anal. Bioanal. Chem. 396(7), 2667-2674 (2010).
