Background
Histone H3K4Me3 (1-25) amide is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-26 of the human histone H3 sequence. Trimetlation of histone H3 at lysine 4 is found in euchromatic promoter regions and is associated with active transcription.1 It inhibits several H3K9 metltransferases and has differential effects on the activities of the KDM7 demetlases PHF8 and KDM7A, activating and inhibiting H3K9Me3 demetlation, respectively. Mislocalization of H3K4Me3 is associated with disease progression and memory deficits in patients with Alzheimer's disease.2
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