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- Ribosomal S6 Kinase (RSK)
- Cryogenine
Cryogenine
An alkaloid with anti-inflammatory activity
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包装价格促销价数量
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1mg￥2587.002070.00- +
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5mg￥11562.009250.00- +
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10mg￥19062.0015250.00- +
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- 货号: ajcx19704
- CAS: 10308-13-1
- 别名: NSC 272693
- 分子式: C26H29NO5
- 分子量: 435.5
- 纯度: ＞98%
- 溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity.1 It inhibits prostaglandin synthetase (IC50 = 424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.2
|1. Lema, W.J., Blankenship, J.W., and Malone, M.H. Prostaglandin synthetase inhibition by alkaloids of Heimia salicifolia. J. Ethnopharmacol. 15(2), 161-167 (1986).|2. Kosersky, D.S., Brown, J.K., and Malone, M.H. Effects of cryogenine on adjuvant-induced arthritis and serum turbidity in rats. J. Pharm. Sci. 62(12), 1965-1971 (1973).
