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A neuropeptide with diverse biological activities
3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) is an intermediate in several metabolic pathways.1,2,3,4 Conversion of HMG-CoA to mevalonate by HMG-CoA reductase is the rate-limiting first step in the cholesterol biosynthetic pathway.2,3 Alternatively, HMG-CoA can be cleaved into acetyl-CoA and the ketone body acetoacetate in mitochondria by HMG-CoA lyase.1,4 HMG-CoA is also an intermediate in the degradation of leucine.4
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