(±)-trans-GK563

A GVIA iPLA2 inhibitor

原价

￥1550-12050

价格

￥ 1240-9640

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库存: 现货

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产品引用

货号: ajcx19712
CAS: 2351820-19-2
别名: GK563
分子式: C16H22O2
分子量: 246.3
纯度: >98%
溶解度: Chloroform: slightly soluble,DMSO: slightly soluble,Methanol: slightly soluble
储存: Store at -20°C
库存: 现货

Background

trans-(±)-GK563 is a potent β-lactone inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (GVIA iPLA2; IC50 = 1 nM).1 It is selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 μM). trans-(±)-GK563 (1 and 10 μM) inhibits apoptosis induced by IL-1β and IFN-γ in INS-1 β-cells.

|1. Dedaki, C., Kokotou, M.G., Mouchlis, V.D., et al. β-Lactones: A novel class of Ca2+-independent phospholipase A2 (group VIA iPLA2) inhibitors with the ability to inhibit β-cell apoptosis. J. Med. Chem. 62(6), 2916-2927 (2019).

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生命科学

有机化学

无机化学

材料科学

(±)-trans-GK563

(±)-trans-GK563详情

Background