(±)-trans-GK563
A GVIA iPLA2 inhibitor
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包装价格促销价数量
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1mg￥1550.001240.00- +
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5mg￥6900.005520.00- +
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10mg￥12050.009640.00- +
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- 货号: ajcx19712
- CAS: 2351820-19-2
- 别名: GK563
- 分子式: C16H22O2
- 分子量: 246.3
- 纯度: ＞98%
- 溶解度: Chloroform: slightly soluble,DMSO: slightly soluble,Methanol: slightly soluble
- 储存: Store at -20°C
- 库存: 现货
Background
trans-(±)-GK563 is a potent β-lactone inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (GVIA iPLA2; IC50 = 1 nM).1 It is selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 μM). trans-(±)-GK563 (1 and 10 μM) inhibits apoptosis induced by IL-1β and IFN-γ in INS-1 β-cells.
|1. Dedaki, C., Kokotou, M.G., Mouchlis, V.D., et al. β-Lactones: A novel class of Ca2+-independent phospholipase A2 (group VIA iPLA2) inhibitors with the ability to inhibit β-cell apoptosis. J. Med. Chem. 62(6), 2916-2927 (2019).
