Gly-Arg-AMC (hydrochloride)
A fluorogenic substrate for cathepsin C
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包装价格促销价数量
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1mg￥600.00480.00- +
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5mg￥2712.002170.00- +
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10mg￥4762.003810.00- +
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25mg￥10437.008350.00- +
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- 货号: ajcx19808
- CAS: 70274-78-1
- 别名: Gly-Arg-7-amino-4-methylcoumarin, GR-AMC, GR-7-amino-4-methylcoumarin
- 分子式: C18H24N6O4.XHCl
- 分子量: 388.4
- 纯度: ＞98%
- 溶解度: DMF: 30mg/mL,DMSO: 30mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL,Ethanol: 20mg/mL
- 储存: Store at -20°C
- 库存: 现货
Background
Gly-Arg-AMC is a fluorogenic substrate for cathepsin C.1 Upon enzymatic cleavage by cathepsin C, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify cathepsin C activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
|1. Rubach, J.K., Cui, G., Schneck, J.L., et al. The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis. Biochemistry 51(38), 7551-7568 (2012).
